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July 10, 2021 4 min read

Vitamin B12 is one of the water soluble vitamins that is essential to the production of red blood cells as well as the maintenance of nerves and is crucial to proper brain function.

It is responsible for the smooth functioning of several critical body processes.
It is possible for the body to Strict vegetarians, heavy drinkers and smokers, pregnant and breast-feeding women, and the elderly usually require vitamin B12 supplements. Sometimes our body, mainly our digestive system, is not able to absorb vitamin B12 well. This can happen when a person has pernicious anemia, celiac disease, Crohn's disease, bacteria growth in the small intestine, or a parasite. People suffering from these conditions may need vitamin B12 supplements, to prevent

a vitamin B12 deficiency. This deficiency is usually reported with symptoms of fatigue.


A deficiency in vitamin B12 can result in a host of illnesses like anemia, fatigue, weakness, constipation, loss of appetite, weight loss, depression, poor memory, soreness of the mouth, asthma, vision problems, and a low sperm count.

Make sure that your body is getting enough vitamin B12.


Vitamin B 12:

  • Is necessary to convert carbohydrates to glucose which leads to increased energy.
  • Increases energy and counteract fatigue and lethargy.
  • Helps to reduce stress and depression.
  • Helps to maintain healthy brain function.
  • Is necessary to regulate cholesterol levels.
  • Assists the body's cell reproduction and is therefore essential to skin and hair as well as all other vital organs.
  • Helps to build your immune system.
  • Is required for red blood cells to form and grow and transport Oxygen
  • Vitamin B12 intake is extremely important during pregnancy or trying to get pregnant.
  • It helps in healthy regulation of the nervous system, reducing depression, stress, and brain shrinkage.
  • Vitamin B 12 helps protect against cancers including breast, colon, lung, and prostate cancer.


Vitamin B12 is vital to cellular reproduction and maintenance. It is absolutely essential in the metabolizing of fats and carbohydrates, and is necessary to the metabolism of every cell in the human body.

Vitamin B12 is necessary for the formation of red blood cells. Red blood cells deliver oxygen to the many trillions of cells. The increased metabolism as a result of increased oxygen delivery allows the body to function at a much higher level of efficiency. This higher functioning metabolism means the body can burn those unwanted calories much more efficiently. If you've been struggling to burn off those unwanted pounds after years of poor dietary habits, you may very well be suffering from a lack of vitamin B12.

Because vitamin B12 is necessary for the formation of red blood cells and all the things red blood cells do for the body (providing life-giving oxygen to the body's trillions of cells), vitamin B12 benefits the body in fighting anemia.

Vitamin B12 is a water soluble vitamin, the human body will only accept and store what it need. If there is an excess, it will be removed through the urine.


Digestion & Absorption Vitamin B12:

Absorbtion of Vitamin B12 in heathy individuals.

Vitamin B12, bound to protein in food, is released by the activity of hydrochloric acid and gastric protease in the stomach. When vitamin B12 is added to fortified foods and dietary supplements, it is already in free form and, thus, does not require this separation step. Free vitamin B12 then combines with Intrinsic Factor, a glycoprotein secreted by the stomach's parietal cells, and the resulting complex undergoes absorption within the distal ileum by receptor-mediated endocytosis. Approximately 56% oral vitamin B12 is absorbed this way.

In addition to the Intrinsic Factor mechanism, Passive Diffusion normally accounts for between 3% and 5% of B12 absorbed when obtained through normal food sources or Vitamin B 12 supplements.

When taken in large enough doses, unbound B12 can overcome Intrinsic Factor defects because much can be absorbed through Passive Diffusion.

Vitamin B12 Plus contains 452mcg Vitamin B12. The NRV for B12 is 2.4mcg/day. In a healthy person with normal IF an absorbtion rate of 56% is equal to 253.12mcg/day or 1771.84mcg/week. Vitamin B12 is a water soluble vitamin, the human body will only accept and store what it need. If there is an excess, it will be removed through the urine.

 This level of absorption and availability surpasses that of a weekly injection of 1000mcg, bear in mind that the immediate excess achieved by injection is slowly removed through the urine, levels can therefore not be maintained for 7days.

In persons suffering from any of the above conditions where the IF is challenged or just not available, B12 is absorbed through Passive Diffusion at a rate of 3-5% which equals 22.6mcg(The NRV is 2.4mcg), this is almost 10 times the NRV and thus can maintain all the daily Vitamin B12 requirements. 

Some people-particularly older adults, those with pernicious anemia, and those with reduced levels of stomach acidity (hypochlorhydria or achlorhydria) or intestinal disorders-have difficulty absorbing vitamin B12 from food and, in some cases, oral supplements. As a result, vitamin B12 deficiency is common, affecting only between 1.5% and 15% of the general population. In many of these cases, the cause of the vitamin B12 deficiency is unknow

Brenda Hutchinson
Brenda Hutchinson

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